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Management of people living with obesity and comorbidities

From shared pathophysiology to shared management

e-Space Obesity online educational program is developed to educate clinicians managing patients with obesity and to increase the awareness of the multidimensional nature and complexity of the disease, including the interconnectivity between obesity and cardio-renal-metabolic complications, such as Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)/Metabolic Dysfunction-Associated Steatohepatitis (MASH), Cardiovascular Disease (CVD) and Chronic Kidney Disease (CKD).

After completing this program, clinicians will be better aware of best practices and recent guidelines on the management of obesity and their patient centric approach.

  • Incorporate treatment strategies based on a better understanding of the pathophysiological complexity of obesity and the interplay between overweight/obesity and the cardio-renal-metabolic syndrome, in patients with comorbidities that include MASLD/MASH, CVD and CKD.
  • Assess the underlying factors contributing to obesity and the multidimensional impact of obesity on people when developing management plans for these patients.
  • Apply a holistic, patient-centered and team-based approach in weight management, incorporating the latest insights into doctor-patient communication and “people-first” language

Understanding the Pathophysiological Complexity of Obesity and Comorbidities

This module will explore the definition, classification, and pathophysiology of obesity, and will provide a comprehensive overview of its
far-reaching health consequences and the need for a systematic, multidisciplinary approach to its management.

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Learning Objectives

Incorporate treatment strategies based on a better understanding of the pathophysiological complexity of obesity and the interplay between overweight/obesity and the cardio-renal-metabolic syndrome, in patients with comorbidities that include MASLD/MASH, CVD and CKD.
  • LO 1 Explain the pathophysiology and the metabolic pathways of obesity.
  • LO 2 Illustrate how obesity impacts the cardiorenal metabolic syndrome.
  • LO 3 Apply the different treatment strategies for obesity.

Faculty

Dr. Onno Holleboom

Dr. Onno Holleboom

Dr. A.G. (Onno) Holleboom MD PhD is an associate professor and internist in Vascular Medicine and Endocrinology at Amsterdam UMC, The Netherlands. He heads a multidisciplinary outpatient clinic for MASLD together with hepatology.

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Dr. Naveed Sattar

Dr. Naveed Sattar

Dr. Naveed Sattar graduated from the University of Glasgow in 1990. In early 1992 he took up his first post as a senior house officer (SHO) at Edinburgh Royal Infirmary; returning to Glasgow later that year as an SHO at the Victoria Infirmary.
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Assessing underlying factors and multidimensional impact of obesity

This module explores the genetic, environmental, behavioral, and psychosocial factors contributing to obesity. It emphasizes individualized assessment, tools for evaluation, and evidence-based management strategies to address obesity’s multidimensional impacts and improve patient outcomes.

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Assessing underlying factors and multidimensional impact of obesity-cover

Learning Objectives

Assess the underlying factors contributing to obesity and the multidimensional impact of obesity on people when developing management plans for these patients.
  • LO 1 Evaluate the physiological, psychological, and environmental contributors to obesity using a comprehensive patient assessment.
  • LO 2 Analyze the physical, psychological, social, and economic consequences of obesity on individuals and healthcare systems.
  • LO 3 Design and implement personalized, multidisciplinary management plans for obese patients with severe comorbidities.

Faculty

Dr. Amalia Gastaldelli

Dr. Amalia Gastaldelli

Dr. Prof. Amalia Gastaldelli, PhD, is a Research Director at the Institute of Clinical Physiology (IFC) of the National Research Council (CNR) in Pisa, Italy, where she heads the Cardiometabolic Risk Group and the Multi-Omics Mass Spectrometry Laboratory.
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Dr. Amalia Gastaldelli

Dr. Marc-André Cornier

Dr. Cornier is a Professor of Medicine with Tenure, James A. Keating Endowed Chair in Diabetes, and Director of the Division of Endocrinology, Diabetes and Metabolic Diseases at the Medical University of South Carolina.

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Holistic, Patient-centered, and team approach in weight management

This module explores holistic and patient-centered care in obesity management. Learn effective communication, reduce stigma with people-first language, and leverage multidisciplinary teams to improve outcomes. Includes real-world examples and case studies for practical insights.
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Holistic,-Patient-centered,-and-team-approach-in-weight-management

Learning Objectives

Apply a holistic, patient-centered and team-based approach in weight management, incorporating the latest insights into doctor-patient communication and “people-first” language
  • LO 1 Apply the principles of holistic and patient-centered care by developing individualized care plans that address physical, emotional, social, and cultural factors impacting the patient's well-being.
  • LO 2 Demonstrate effective communication skills by using people-first language to respectfully and empathetically engage with patients and colleagues, fostering a positive and inclusive healthcare environment.
  • LO 3 Ability to collaborate with interdisciplinary team members to design and implement comprehensive weight management strategies that integrate medical, nutritional, behavioral, and psychosocial interventions

Faculty

Dr. Sarah Jarvis

Dr. Sarah Jarvis

Dr. Sarah trained at Cambridge and Oxford universities and became a partner in an inner city general practice in 1990. She was a GP trainer for 25 years until 2017. She is an active medical writer and broadcaster and is the resident doctor…
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Dr Robert F Kushner

Dr. Robert F Kushner

After finishing a residency in Internal Medicine at Northwestern University, Dr. Kushner went on to complete a postgraduate fellowship in Clinical Nutrition and earned a master’s degree in clinical nutrition and nutritional biology…
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Dr. Onno Holleboom

Dr. Onno Holleboom

Dr. A.G. (Onno) Holleboom MD PhD is an associate professor and internist in Vascular Medicine and Endocrinology at Amsterdam UMC, The Netherlands. He heads a multidisciplinary outpatient clinic for MASLD together with hepatology. Supported by the Dutch gastroenterology and hepatology foundation, his team investigates and implements care paths for MASLD. He is on the executive board of the IHI GRIP on MASH consortium, has co-authored the Dutch MASLD guideline 2024 and was on the Delphi panel for the EASL-EASD-EASO MASLD guideline 2024. He runs a research group with 6 PhD candidates focusing on genetic and gut microbial drivers of MASLD and on pathways around liver sinusoidal endothelium.

Dr. Naveed Sattar

Dr. Naveed Sattar

Dr. Naveed Sattar graduated from the University of Glasgow in 1990. In early 1992 he took up his first post as a senior house officer (SHO) at Edinburgh Royal Infirmary; returning to Glasgow later that year as an SHO at the Victoria Infirmary. In 1993 he moved to Glasgow Royal Infirmary, first as a Specialist Registrar then as Senior Lecturer and Reader. He was awarded a PhD from the University of Glasgow in 1998.

He joined the staff of the University of Glasgow and in early 2005 was appointed as Professor of Metabolic Medicine at the Institute of Cardiovascular & Medical Sciences (now School of Cardiovascular and Metabolic Health). He continues as an Honorary Consultant in Metabolic Medicine at the Glasgow Royal Infirmary, where he co-leads a CVD prevention clinic. He is a Fellow of the Royal College of Pathologists; the Royal College of Physicians and Surgeons, Glasgow; the Royal Society of Edinburgh; and the UK Academy of Medical Sciences.
He is regularly asked to speak at international conferences and has sat on several national and international guideline committees, including: European Society of Cardiology (ESC) Task Force to develop 2023 Guidelines on diabetes and cardiovascular disease; Joint British Societies 3 CVD prevention recommendations; SIGN obesity and CVD prevention guidelines (latter as Chair); and European CVD prevention guidelines. In later 2023 he was appointed as the UK Government’s new Obesity Mission Chair.

He has epidemiology, mechanistic and trial expertise in diabetes, obesity and cardiovascular disease, having contributed to several lifestyle (e.g. DIRECT, STANDBY, UPBEAT, EUROFIT) and drug (e.g. REMOVAL, TRUST, AMPLITUDE-O, EMPEROR Heart failure) trials, with ongoing activity in several outcome trials. He is an Associate Editor for Diabetes Care and is on the editorial boards for BMC Medicine and Diabetes & Metabolic Syndrome: Clinical Research & Reviews. He has previously been an Associate Editor for Circulation and sat on committees for Diabetologia, Diabetes Digest, Diabetes UK, European Association for Study of Diabetes (EASD), Lancet Diabetes and Endocrinology, American Diabetes Association, Scotland’s Chief Scientist Office, British Heart Foundation, and UK Biobank.
He has authored / co-authored over 1200 published papers and has been cited more than 120k times (Web of Science) and >200K (google scholar). He has been in the top 1% of cited clinical academics in the world since 2014, according to the annual Clarivate Analytics Highly Cited Researcher list. He has received several national and international prizes for his research, including the following lectures: Banting Memorial, Camillo Golgi, Dorothy Hodgkin, Minkowski, John French Rank Nutrition, and the and the RD Lawrence Lecture.

Dr. Amalia Gastaldelli

Dr. Marc-André Cornier

Dr. Cornier is a Professor of Medicine with Tenure, James A. Keating Endowed Chair in Diabetes, and Director of the Division of Endocrinology, Diabetes and Metabolic Diseases at the Medical University of South Carolina. Dr Cornier has focused his career on cardiometabolic diseases such as obesity, diabetes, and lipid disorders.

Prior to that Dr. Cornier received his undergraduate education at Vanderbilt University and medical doctorate at the Medical College of Georgia. He completed an internal medicine residency at Georgetown University Medical Center followed by a fellowship in Endocrinology, Metabolism and Diabetes at the University of Colorado. 

He was then on faculty at the University of Colorado with the Division of Endocrinology, Metabolism and Diabetes until 2021. Since then, Dr Cornier continues to focus on cardiometabolic diseases such as diabetes, lipid disorders and obesity at MUSC. He is an active clinical and translational investigator with a primary research interest in body weight regulation and in studying optimal interventions for weight management and metabolic health. 

He is also actively involved in clinical trials for investigational treatments for lipid disorders, diabetes and obesity. Dr. Cornier has been an active volunteer and leader in a number of important health-related associations and currently serves as the President of The
Obesity Society.

Dr. Amalia Gastaldelli

Dr. Amalia Gastaldelli

Dr. Prof. Amalia Gastaldelli, PhD, is a Research Director at the Institute of Clinical Physiology (IFC) of the National Research Council (CNR) in Pisa, Italy, where she heads the Cardiometabolic Risk Group and the Multi-Omics Mass Spectrometry Laboratory. She is also Adjunct Professor of Medicine at the Diabetes Division of the University of Texas Health, in San Antonio, TX, USA, and Affiliate Professor at the Institute of Life Sciences of the Sant'Anna School of Advanced Studies in Pisa. She graduated from the University of Padova and obtained a PhD in Preventive Medicine with a specialization in Human Pathophysiology from the University of Texas Medical Branch and a PhD in Biomedical Engineering from the Politecnico di Milano.

Dr Gastaldelli's research focuses on the physiological mechanisms of metabolic diseases (mainly Metabolic dysfunction Associated Steatotic Liver Disease (MASLD), Obesity and Type 2 Diabetes) with particular focus on the alteration of metabolic fluxes and hormone secretion and action studied in vivo using novel techniques based on mass spectrometry and modeling analyses.

She is currently President of the European MASLD Study Group affiliated to the EASD, which she founded in 2012 and provides a joint forum for diabetologists and hepatologists to explore the diagnosis, pathogenesis and treatment of MASLD and MASH and since 2018 President of the EGIR (European Group for the study of Insulin Resistance) Study Group also affiliated to the EASD. From 2010 to 2020 she chaired the European Chapter of the American College of Nutrition (ECACN) and was a member of the Board of Directors of the American College of Nutrition (ACN). In 2016 and 2023 she was part of the EASL-EASD-EASO committees (delegate of EASD) to write the European clinical guidelines for the management of NAFLD/MASLD.

Dr. Sarah Jarvis

Dr. Sarah Jarvis

Dr. Sarah trained at Cambridge and Oxford universities and became a partner in an inner city general practice in 1990. She was a GP trainer for 25 years until 2017. She is an active medical writer and broadcaster and is the resident doctor for BBC Radio 2 and ITV lunchtime news. She also appears regularly on UK television and radio programmes including Channel 5, the One Show on BBC One, Good Morning Britain, LBC and Radio 5 live. 

From 2017-22 she was clinical director of the website Patient.info, which provides patient health education to over 120 million people a year worldwide. She now acts as a clinical consultant for them. 

Dr Jarvis is past chair of the Health Care Committee of HEART UK, the cholesterol charity, and is a member of the advisory board for the British Journal of Cardiology. She is also past Chair of the Women’s Taskforce at the RCGP and Women’s Health Spokesperson for the RCGP.
She has also authored Diabetes for Dummies (now in its third edition), Pregnancy for Dummies, Children's Health for Dummies, Women's Health for Life and The Welcome Visitor, a book on the ethics of dying co-authored with the broadcaster John Humphrys.
Sarah was appointed an MBE (Member of the Order of the British Empire) in the New Year’s Honours list in December 2017 for services to public understanding of health and general practice.

In February 2021 Sarah was appointed Visiting Professor of General Practice at the University of Huddersfield.

Dr Robert F Kushner

Dr Robert F Kushner

After finishing a residency in Internal Medicine at Northwestern University, Dr. Kushner went on to complete a postgraduate fellowship in Clinical Nutrition and earned a master’s degree in clinical nutrition and nutritional biology from the University of Chicago, IL. Dr Kushner is past President of The Obesity Society, the American Society for Parenteral and Enteral Nutrition, and the American Board of Physician Nutrition Specialists (ABPNS), and a founder and first Chair of the American Board of Obesity Medicine (ABOM). Dr Kushner has authored over 250 original articles, reviews, books and book chapters covering nutrition, obesity, and medical education, and is an internationally recognized expert on the care of patients with overweight or obesity. He is author/editor of multiple books; current books include Nutrition and Bariatric Surgery (CRC Press, 2015), Lifestyle Medicine: A Manual for Clinical Practice (Springer, 2016), Creating a Lifestyle Medicine Center (Springer, 2020), Six Factors to Fit – Weight Loss that Works for You! (Eat Right Press, 2020), and Primary Care: Evaluation and Management of Obesity (Wolters Kluwer, 2022).